SYN2 and neurodegenerative disease: Among the 18 genes (ATXN1 appears in both categories), 5 of them have been confirmed by OMIM and GAD (Genetic Association Database) (Becker et al., 2004), of which 2 (RASA1 and ATXN1) are cardiovascular disease-related and 4 are neurodegenerative disease-related (ATXN1, EPB41L1, PNPLA6, SYN2), whereas the rest only appear in one database.