KDR and neoplasm: This peptide (VEGF-P3-CYC) inhibited the proliferation, migration and tube formation, as well as VEGFR2 phosphorylation in human umbilical vein endothelial cell (HUVEC) in vitro, and when injected to the transgenic VEGF+/−Neu2-5+/− mouse model, the peptide significantly delayed tumor growth (60).