IRF7 and mixed connective tissue disease: Figure 4C shows the DNAm profile across the different diseases and the healthy population for the top differentially methylated genes. CpG cg12037516 (IRF7 gene) showed the largest DNAm difference between MCTD and SjS patients. CpG cg13452062 (IFI44L gene) showed the largest DNAm difference between MCTD and RA patients. And finally, the CpG cg01028142 (CMPK2 gene) showed the largest DNAm difference between MCTD and SSc.