H-1PV combinations with chemotherapeutics (160, 179), histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) (180) and immune checkpoint blockade (181) have been demonstrated to synergistically potentiate the double-faceted anticancer activity of the virus by both inducing enhanced virus replication, oxidative stress and tumor cell lysis (180), and exerting immune stimulatory effects (160, 181) in tumor cell and animal models. The gene discussed is HDAC9; the disease is neoplasm.