Accordingly, injection of mice with either the transactivator of transcription (TAT)-glutathione-S-transferase (GST)-GILZ (TAT-GST–GILZ) fusion protein or high doses of DEX, which upregulates GILZ in mucosal T lymphocytes, rescues mice from Th-1-mediated experimental colitis, again by inhibiting NF-κB (45). This evidence concerns the gene NELFCD and colitis.