Indeed, DSG1-positive (Figure 1A) and DSG3-positive (Figure 1B) B cells were detectable in HD, although at a lower frequency than in the 20 patients with active pemphigus (DSG1 positive 0.11 vs. 0.20%, p < 0.001; DSG3 positive 0.10% vs. 0.20%, p < 0.001). This evidence concerns the gene DSG1 and pemphigus.