IFN-α stimulates neutrophils in SLE patients to form NETs in the presence of anti-ribonucleoprotein (RNP) antibodies. The formed NETs contain non-engulfed chromatin that facilitates DNA uptake by PDCs. NETs are the source of the elevated cfDNA levels in SLE patients (14). Here, RNPC3 is linked to systemic lupus erythematosus.