CD40LG and systemic lupus erythematosus: Lower baseline serum IgM levels and sequential therapy with mycophenolate mofetil can predict IgM hypogammaglobulinemia after rituximab treatment in patients with SLE. No significant change in anti-dsDNA antibodies was observed in patients with initially higher levels, even after treatment. This finding suggests that high SLE disease activity is associated with dsDNA autoantigens in serum (29).