The intramacrophage growth of Salmonella enteritidis C50041 with a spiC-deletion was continuous, while the number of wild-type Salmonella began to reduce from 10 to 24 h post infection, but the load of spiC-deleted mutants began to increase, which was significantly higher compared with that of the wild-type Salmonella in RAW264.7 macrophages at 24 h post infection (Data by our Lab). This evidence concerns the gene SPIC and infection.