MOG and leukodystrophy: Hacohen et al. (12) proposed that children with MOG-Ab might present with four MRI patterns: (1) multifocal hazy/poorly marginated lesions involving both the gray and white matter and typically involving the middle cerebellar peduncles; (2) spinal cord and/or optic nerve involvement with a normal intracranial appearance or non-specific white matter lesions; (3) extensive and periventricular white matter lesions resembling a “leukodystrophy-like” pattern; and (4) cortical encephalitis with leptomeningeal enhancement.