PTEN and glioblastoma: In GBM, caspase-3 and PTEN in tumoral cells are the only two identified targets of S-nitrosylation that contribute to glioma expansion (Yu et al., 2005; Shen et al., 2016), however, the contribution of S-nitrosylation of endothelial proteins to GBM physiopathology has not been investigated yet.