TLR4 also contributes to the development of cardiac remodeling following pressure overload, myocardial infarction, angiotensin II, or ISO infusion in vivo (Ha et al., 2005; Timmers et al., 2008; Dange et al., 2014; Dong et al., 2015; Han et al., 2017; Katare et al., 2017). The gene discussed is AGT; the disease is myocardial infarction.