Similar to our results, using different H2 delivery methods, Atsunori Nakao group and others have also indicated that H2 can decrease these pro-inflammatory cytokine levels in the target tissue or in serum in LPS-induced bowel dysfunction (LPS: 15 mg/kg) (Sakata et al., 2017) or acute lung injury [LPS: 25 μg/mouse (Xie et al., 2012) or 15 mg/kg (Liang et al., 2012)] or GalN/LPS-induced acute liver injury (LPS: 20 μg/kg) (Sun et al., 2011). Here, GAL is linked to bowel dysfunction.