PTGS2 and non-small cell lung carcinoma: Moreover, we revealed that cisplatin induced PTGS2 expression through the ROS-ERK1/2-NF-κB signaling axis, and PGE2 might strengthen PTGS2 expression through the PGE2-EPs-ERK1/2 positive feedback loop, which induced multidrug resistance of NSCLC cells via mediating the augmentation effects of cisplatin on BCL2 expression and the subsequent impairment of cell apoptosis.