We specifically focused on the role of the MR, in view of recent evidence supporting that some MR haplotypes confer resilience to depression in a sex-dependent manner (Vinkers et al., 2015); this does not negate that variants of the GR gene may also contribute to the vulnerability to develop psychopathology in the face of early life events (e.g., Sarubin et al., 2017). The gene discussed is NR3C1; the disease is major depressive disorder.