BDNF and Alzheimer disease: Furthermore, 7,8-dihydroflavone (7,8-DHF), Neotrofin (a hypoxanthine derivative that stimulates neurotrophic factor production) and Neuropep-1 (a BDNF modulating peptide) have shown to reverse memory deficits in animal models of AD or even in preclinical trials (Glasky et al., 1994; Devi and Ohno, 2012; Shin et al., 2014).