CD8A and Autoimmunity: Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8) was also one of the most significantly upregulated genes at 60 dpi, and is known to regulate the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity (Oflazoglu et al., 2009; Figure 2E).