GPHN and epilepsy: Since dysfunctional inhibitory neurotransmission triggered by defects residing in either the receptors or gephyrin has been implicated in a diverse set of neurodevelopmental disorders including anxiety and epilepsy (Agarwal et al., 2008; Hales et al., 2013; Dejanovic et al., 2014, 2015), these macromolecules may be suitable targets of future structure-based drug discovery processes.