On the other hand, the downregulated genes comprised of bone morphogenetic protein 4 (Bmp4), fibroblast growth factor receptor 2 (Fgfr2), GLI-Kruppel family member GLI2 (Gli2), Nestin, SRY-box containing gene 2 (Sox2), which are involved in cytoskeletal organization and differentiation of neurons and are reportedly affected in depression models. This evidence concerns the gene NES and major depressive disorder.