P2RX7 and familial pancreatic carcinoma: In another study on neuroblastoma cells, P2X7 inhibition was associated with neuritogenesis and increased Akt phosphorylation (Gomez-Villafuertes et al., 2009) and in pancreatic cancer cells, P2X7 activation was involved in activation of protein and lipid phosphatases that lead to nuclear Akt depletion and inhibited proliferation (Mistafa et al., 2010).