Furthermore, several experiments confirmed that transplantation of various stem cells had anti-inflammatory effects in the treatment of stroke, although the results did not explicitly state that the regulation of inflammation was induced by CD200-CD200R because of the inadequate analysis of CD200 distributed on the surface of stem cells (Borlongan et al., 2010; Eckert et al., 2015; Yoo et al., 2016). This evidence concerns the gene CD200 and stroke disorder.