Lago et al. (2018) observed that the level of proinflammatory cytokines increased using a selective blocking antibody against CD200R1; this finding indicates that the destruction of CD200R1 induced microglial cells to exhibit a proinflammatory phenotype. Liu et al. (2010) administered a CD200R1 agonist (CD200Fc) in mice with experimental autoimmune encephalomyelitis (EAE) during the chronic phase of the disease; they found that the activation markers of microglia were decreased. This evidence concerns the gene CD200R1 and experimental autoimmune encephalomyelitis.