THY1 and Parkinson disease: As various studies have implicated microbially-derived LPS in PD pathogenesis (Forsyth et al., 2011; He et al., 2013; Kelly et al., 2014; Sharma and Nehru, 2015; Choi et al., 2018), this study was the first to investigate the role of LPS as a catalyst for intestinal permeability and phenotypic change in Thy1-αSyn mice.