Cortical neurons prepared from 8-oxodeoxyguanine/8-oxoguanine glycosylase (8-oxo-dG/OGG1) double deficient adult mouse brains exhibit increased 8-oxoguanine (8-oxoG) accumulation in mitochondrial DNA and significantly poor neuritogenesis in vitro in the absence of antioxidants in AD (Abolhassani et al., 2017). This evidence concerns the gene OGG1 and Alzheimer disease.