In addition to the EMT and angiogenesis process induced by MDM2 overexpression in tumor cells, Zou et al. confirmed that MDM2 can act as an E3 ubiquitin ligase and reduce T cell activation by degrading transcription factor NFATc2 [47], resulting in the resistance to PD-1 inhibitors of malignancies. This evidence concerns the gene MDM2 and neoplasm.