Conditioned media obtained from ATP-stimulated WT macrophages increased the invasive potential of melanoma cancer cells (B16F10) (WT, vehicle vs WT, ATP: 132 ± 38.05 vs 564.6 ± 133.52) (Fig. 2C,D) while conditioned media collected from NLRP3 KO macrophages stimulated with ATP failed to enhance invasion of cancer cells (WT, ATP vs KO, ATP: 564.6 ± 133.52 vs 170.6 ± 55.48) (Fig. 2C,D). Here, NLRP3 is linked to cancer.