Finally, using gene expression data from within a cohort of DIPG biopsy specimens32, we identified a strong inverse correlation between PPM1D and NAPRT mRNA levels (Supplementary Fig. 9c), as well as a trend of decreased NAPRT expression in known PPM1D mutant tumor samples (Fig. 4c; Supplementary Fig. 9d). The gene discussed is NAPRT; the disease is neoplasm.