TMEM11 and neoplasm: The following automatic tags are implemented per their ACMG specifications: PVS1 (truncating variant in a tumor suppressor or other loss-of-function gene), PM1 (somatic hotspot in COSMIC), PM2 (absent from ExAC non-TCGA or appearing at a frequency not greater than 0.0001) and the companion BA1 tag (>5% population frequency in ExAC non-TCGA), PM4 (in-frame protein insertions and deletions), PS1, and PM5 (amino acid comparisons made vs. pathogenic variants in ClinVar or those identified by the St.