Altered anxiety and fear response was also noted in Iqsec2 KO female mice, with a significant increase in percentage total distance travelled in the inner third of the open-field apparatus (Fig 3C and P = 0.0006), increased number of head dips on the elevated zero maze (Fig 3D and P < 0.0001), and an initial increase in percentage total distance travelled in the open arms of the elevated zero maze (Fig S5B and P = 0.0007). The gene discussed is IQSEC2; the disease is Anxiety.