APP and Alzheimer disease: Gamma disruption has been demonstrated in other AD mouse models, such as the APP/PS1 model (Klein et al., 2016), the TAS10 overexpression model (Driver et al., 2007) and in the entorhinal cortex of AppNL-G-F knock-in (KI) mice (Nakazono et al., 2017), and these impairments occur relatively early in Aβ-driven pathological processes.