On the other hand, ATP5A1 and NDUFB11 commonly have functional interactions with mitochondrial metabolic factors such as MT-CO2 (mitochondrially encoded cytochrome c oxidase II), MT-CYB (mitochondrially encoded cytochrome b), MT-ND1 (mitochondrially encoded NADH dehydrogenase 1) and MT-ND4 (mitochondrially encoded NADH dehydrogenase 4), suggesting a possible involvement of these molecules in dysregulation of mitochondrial function in C9-ALS cells. The gene discussed is MT-ND4; the disease is amyotrophic lateral sclerosis.