Grade 3 treatment-related AESIs occurred in 4/58 patients (7%): ALT and AST increases and autoimmune hepatitis (n = 1, discontinued treatment as described above); lipase increase (n = 1, resolved); AST increase and myasthenia gravis (n = 1, both resolved); and diarrhea (n = 1, resolved; no report of colitis). The gene discussed is GPT; the disease is colitis.