Recently, preliminary efficacy data from a phase 1 dose escalation and expansion trial by Wainberg et al. looking at a combination of anti-CSF-1R (cabiralizumab) and anti-PD-1 mABs reported an objective response rate of 13% (four patients) amongst a cohort of 31 patients with advanced pancreatic cancer and most of whom were heavily-pretreated. This evidence concerns the gene CSF1R and familial pancreatic carcinoma.