However, in a canine lymphoma and osteosarcoma studies, it was shown that EZN-3042 inhibits growth, induces apoptosis and enhances chemosensitivity in canine lymphoma and osteosarcoma cells, and inhibits survivin transcription and protein production in orthotopic canine osteosarcoma xenografts [145]. This evidence concerns the gene BIRC5 and osteosarcoma.