BIRC5 and neoplasm: The first-in-human PK studies of LY2181308 indicated that among 40 patients treated with LY2181308 at doses of 100 to 1000 mg, 26 patients were evaluated at the recommended Phase 2 dose (750 mg), and demonstrated that LY2181308 accumulated in tumor tissue, reduced survivin mRNA and protein expression by 20%, and restored apoptotic signaling in tumor cells in vivo and exhibited rapid tissue distribution and terminal half-life of 31 days [134].