BIRC5 and malignant colon neoplasm: Since the use of survivin-2B80-88 peptide alone for immunotherapy was unable to elicit enough effects for routine clinical use, these authors assessed survivin-2B80-88 plus incomplete Freund's adjuvant (IFA) versus survivin-2B80-88 plus IFA and IFN-α for clinical trials in patients with advanced colon cancer [159].