BIRC5 and urinary bladder carcinoma: The survivin antisense DNA oligonucleotide ISIS 23722 (5’-TGTGCTATTCTGTGAATT-3’, the bolded bases are the 2’-O-methoxyethyl nucleosides) was initially identified as the most active oligonucleotides by screening of 40 2’-O-methoxyethyl chimeric phosphorothioate oligonucleotides for inhibition of survivin mRNA in T24 bladder carcinoma cells using real-time qRT-PCR [103].