SP1 and cancer: For example, YM155 downregulated survivin through blocking Sp1 and ILF3/p54nrb-mediated constitutive expression of survivin [41–43]; this appears to remove the transcription factors (Sp1, ILF3/p54nrb) from the nucleoplasm to the nucleolus [43], instead of degradation of them; this could give cancer cells an opportunity to recover quickly after removal of YM155.