BIRC5 and prostate carcinoma: The two most potent survivin modulators, LLP3 and LLP9 (Figure 1k, l) caused major mitotic defects including delay of mitotic progression in proliferating human umbilical vein endothelial cells (HUVEC) and PC-3 prostate cancer cells at the concentration range of 50 nM to 100 nM [28].