Recurrent malignant glioma patients with survivin-positive tumors and having either HLA-A*02 or HLA-A*03 MHC class I allele-positivity were given subcutaneous injections of SurVaxM (500 μg) in Montanide ISA 51 with sargramostim (100 μg) at 2-week intervals [162]. This evidence concerns the gene HLA-A and malignant glioma.