Additionally, ESCC patients with high S1PR1 expression have a shorter overall survival (median survival 47 months,95%CI 0.9370 to 2.360) comparing to patients with low S1PR1 expression (median survival 70 months, 95%CI 0.4236 to 1.067) (Fig. 1c). The gene discussed is S1PR1; the disease is esophageal squamous cell carcinoma.