In the top 10 up-regulated circRNAs, we found that circNHSL1, also named hsa_circ_0006835 according to the annotation of circBase (http://www.circbase.org/), was the highest up-regulated circRNA in gastric cancer tissues with metastasis, which was spliced from NHSL1 gene located at chr6: 138,743,180–138,893,726 and finally formed a sense-overlapping circular transcript of 335 nt (Fig. 1b). The gene discussed is NHSL1; the disease is gastric cancer.