The results showed that overexpression of SIX1 reversed the ability of circNHSL1 silencing to suppress the mobility, migration and invasion of gastric cancer cells (Fig. 3i), while down-regulation of SIX1 decreased the enhanced ability of mobility, migration and invasion induced by overexpression of circNHSL1 (Fig. 3j). This evidence concerns the gene SIX1 and gastric cancer.