Several members (e.g. METTL3, METTL14, FTO, ALKBH5 and YTHDF2) actively participate in human cancers such as acute myeloid leukaemia (AML) [25], glioblastoma [26], breast cancer [27] and endometrial cancer [28]. The gene discussed is ALKBH5; the disease is acute myeloid leukemia.