Through infecting RAW264.7 macrophage cells with different bacteria (including the B. suis S2 strain, L. monocytogenes and E. coli) followed by detection of the differential expression of Prdx6, and through regulating the overexpression and knockdown of MmPrdx6 in macrophage cells followed by quantification of viable intracellular bacteria, it was confirmed that infection of cells with L. monocytogenes and E. coli showed little involvement of intracellular Prdx6, but host Prdx6 contributed to the intracellular survival of B. suis S2 strain in cells. This evidence concerns the gene PRDX6 and infection.