Then, differential expression analysis of Prdx6 in macrophage cells was performed after infection with vaccine strain S2 of B. suis, L. monocytogenes and E. coli, and the effects of differential Prdx6 expression on the intracellular survival of bacteria were analysed to better understand the relationship between host Prdx6 and Brucella infection. The gene discussed is PRDX6; the disease is infection.