In addition, the expression and activation of ERS related signaling molecues GRP78/PERK/EIF2α/NFκB, which had been obviously increased in HFD + CCl4 group, was down-regulated by JZG, suggesting that regulating ERS is part of the effective mechanism to improve the sensitivity of liver injury in NAFLD (Fig. 8). Here, HSPA5 is linked to metabolic dysfunction-associated steatotic liver disease.