EIF2AK3 and metabolic dysfunction-associated steatotic liver disease: In addition, the expression and activation of ERS related signaling molecues GRP78/PERK/EIF2α/NFκB, which had been obviously increased in HFD + CCl4 group, was down-regulated by JZG, suggesting that regulating ERS is part of the effective mechanism to improve the sensitivity of liver injury in NAFLD (Fig. 8).