Moreover, higher numbers of α4β1 and αMβ2 integrins in an activated state are related with better eosinophil arrest on endothelium cells that express elevated amount of vascular cell adhesion molecules-1 (VCAM-1) – the ligand for α4β1 [32] and intercellular adhesion molecule-1 (ICAM-1) for αMβ2 [33] thus contributing to increased eosinophilic airway inflammation. Here, VCAM1 is linked to inflammation.