TARDBP and amyotrophic lateral sclerosis: In particular, we see widespread hyperphosphorylated tau and amyloid-beta (Aβ) pathologies, similar to those seen in AD patients [12, 13], as well as TAR DNA protein 43 (TDP-43), which has been implicated in the pathology of Amyotrophic Lateral Sclerosis (ALS) [14, 15].