We have performed RNAi experiments to analyze the expression of three poorly investigated isoforms II-IV of the epidermal growth factor receptor in glioblastoma cell line SF767 with an adjustable EGFR-signaling pathway, and we have developed the Bayesian Gene Selection Criterion (BGSC) approach for the prediction of putative target genes of these EGFR isoforms under the simplifying assumption of neglecting the different binding affinities of the EGFR isoforms to EGF. The gene discussed is EGFR; the disease is glioblastoma.