In vivo similar results were observed, along with increased pSmad2/3 signalling in the stroma of collagen-7 deficient SCC tumours, implying that collagen-7 acts as a TGFβ suppressor, and consistent with αvβ6-dependent TGFβ1 activation inducing fibroblast to myofibroblast transition [114]. This evidence concerns the gene TGFB1 and neoplasm.