LEP and Insulin resistance: To assess the metabolic effects of the sour cherry extract, we investigated the glucose tolerance (fasting blood glucose and insulin response to oral glucose load), measured the levels of adipokines associated with body weight gain and insulin resistance such as leptin, IL-6, MCP-1, resistin, and adiponectin, and examined the antioxidant ability of the chronic sour cherry treatment by determining water-soluble antioxidant capacity (ACW) and superoxide dismutase (SOD) activity.