Markedly, p21 has been shown to attenuate EMT in cell lines and in mouse models: p21 inhibits EMT in colorectal cancer cells and normal human mammary epithelial cells (MCF10A) either in complex with zinc finger E-box binding homeobox 1 (ZEB1) through distinct miRNA clusters [99] or in response to transforming growth factor-β (TGF-β) [100]. This evidence concerns the gene ZEB1 and colorectal cancer.