Oppositely, the complex of cytoplasmic p21 together with ectopic expressed cytosol-resided p53 (mutation in its nuclear localization sequence) suppresses cell invasion due to favoring apoptotic induction by targeting B-cell lymphoma 2 family proteins in non-small cell lung cancer cell line H1299 [133]. This evidence concerns the gene CDKN1A and non-small cell lung carcinoma.