Because various types of tumors produce several cytokines (IL-6, IL-8, TNFα) and growth factors (G-CSF), which are known to stimulate the activity of neutrophils [30,31,32], we aimed to investigate the influence of tumor-derived G-CSF on NET formation by the neutrophils isolated from the blood of HNC patients. The gene discussed is CXCL8; the disease is neoplasm.