CHD4 and neoplasm: Interestingly, we found that CHD4 over-expression was an independent factor in the poor prognosis of MeFS (HR, 4.575; 95% CI, 1.717–12.192; p = 0.002), after adjusting for other clinical and pathological features, like tumor regression grade, vascular invasion, post-Tx tumor status, pre-Tx tumor status, pre-Tx nodal status, and perineural invasion.