Regarding gene regulation, previous study indicated that CHD4 cooperates with DNA methyltransferases (DNMTs) in the silencing of many tumor suppressor genes (TSGs), including MLH1, SFRP1, SFRP2, SFRP4, TIMP2, and TIMP3 to drive the Wnt pathway in CRC cells [24]. The gene discussed is CHD4; the disease is colorectal carcinoma.