Yet, recent studies investigating the functional consequences of NKG2D ligand shedding have challenged the idea that soluble ligands are exclusively immunosuppressive; in human cancers, shedding of MHC class I polypeptide related sequence A (MIC-A), a low-affinity NKG2D ligand, facilitates immune evasion [133,134]; however, shedding of the high-affinity murine analogue, MULT-1, enhances NK cell activation and tumor rejection [135]. The gene discussed is MICA; the disease is cancer.