MAP2K7 and non-small cell lung carcinoma: However, in advanced NSCLC patients (incorporating KRAS mutant LAC), the systemic blockade of the ERK MAPK pathway with MEK inhibitors trametinib and selumetinib, used either as a monotherapy or in combination with standard chemotherapy (i.e., docetaxel), has yielded limited clinical benefit associated with acquired resistance and an unfavourable toxicity profile [25].