Regarding lung cancer, blocking of IL-6 trans-signaling using sgp130Fc—which is a fusion protein of sgp130 and the crystallizable fragment of immunoglobulin G1—or the anti-IL-6R monoclonal antibodies 1F7 and 25F10, ameliorated tumourigenesis in the oncogenic KrasG12D-induced LAC mouse model [29,97,218]. Here, IL6R is linked to lung carcinoma.