In girls, replacing the correlation between the methylation and anxiety-depression factors by a causal effect, higher NR3C1 methylation at 14 months, was associated with higher anxiety-depressed symptoms (standardised coefficient 0.36 CI 0.05 to 0.67, p = 0.025), illustrated in the left-hand panel of Figure 5. This evidence concerns the gene NR3C1 and depressive symptom measurement.