Several T-cell derived cytokines were found in AD skin (e.g., IL-4, IL-13, IL-17A, IL-22, IL-25, or TNF-α) and these cytokines were shown to reduce the expression of several SC barrier proteins such as filaggrin, loricrin, S100A11, and involucrin [10,11,12]. The gene discussed is IL4; the disease is Alzheimer disease.