Moreover, concomitant loss of CRB1 in Crb1KOCrb2ΔimmPRC retinas exacerbated the retinal phenotype and resulted in an LCA phenotype with thickened superior retina due to abnormal lamination of photoreceptors, intermingled photoreceptor and inner nuclear cell nuclei, and ectopic photoreceptor nuclei in the ganglion cell layer [21]. Here, CRB1 is linked to Leber congenital amaurosis.