Although most normal tissues showed non-significant association between the expression of ANRIL and genes belonging to the p16-CDKN2A/p15-CDKN2B/p14-ARF gene cluster, high positive correlations were identified between ANRIL and p16-CDKN2A, p15-CDKN2B, and p14-ARF genes in the great majority of malignant tumors, suggesting coordinated alterations of their regulation in all types of cancers. This evidence concerns the gene CDKN2B and cancer.