P15-CDKN2B was mainly upregulated in pancreas (91%), thyroid (78%), and kidney (77%) carcinomas, whereas p15-CDKN2B underexpression was identified in colon (90%) carcinomas, skin melanomas (59%), and head and neck squamous cell carcinoma (HNSCC; 38%) (Supplementary Figure S2C,D). Here, CDKN2B is linked to carcinoma.