This lncRNA acts mainly in cis at the p16-CDKN2A/p15-CDKN2B/p14-ARF cluster, whose three tumor suppressor genes are involved in stem cell renewal, senescence, and apoptosis by promoting anti-proliferative and pro-apoptotic activities of Rb1 and p53 [5]. Here, CDKN2B is linked to neoplasm.