CDKN2A and cancer: Despite important progress, ANRIL deregulation in cancer remains largely unknown, and only a few mechanisms have recently been evocated, such as ANRIL and p16-CDKN2A promoter methylation status regulating ANRIL/p16-CDKN2A and ANRIL/p14-ARF transcription [29,30] and transcription factors activating ANRIL transcription [31,32,33].